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HRR Panel

Catalog Number:

#1001931

HRR Panel v1.0 targets whole coding sequences of 35 DNA Homologous recombination repair (HRR) related genes. It can be used alone for HRR gene mutation analysis, as well as spike-in to HiSNP-series panel forHomologous Recombination Deficiency (HRD) assessment by analyzing genomic instability along with HRR-related gene mutation.

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Gene List

Genes with coding regions covered

ATM	ATR	BARD1	BLM	BRCA1	BRCA2	BRIP1	CDK12	CHEK1	CHEK2	FANCA	FANCC
FANCD2	FANCE	FANCF	FANCG	FANCI	FANCL	FANCM	MRE11	NBN	PALB2	RAD50	RAD51
RAD51B	RAD51C	RAD51D	RAD52	RAD54L	RBBP8	RPA1	SLX4	XRCC2	TP53	PPP2R2A

Capture Performance

Pic1. Capture performance of HRR Panel v1.0. DNA libraries of human genomic DNA, male (Promega, G1471) were prepared by using the NadPrep DNA Library Preparation Kit (for Illumina®), and captured by using HRR Panel v1.0. The A. mapping rate, on-target rate, coverage uniformity, and B. coverage consistency were exhibited, respectively.Sequencing platform is NovaSeq 6000 with PE150.

Variant analysis

Pic2. Variant analysis by HRR Panel v1.0. DNA libraries of Onco gDNA (Genewell, GW-OGTM800) were prepared by using the NadPrep DNA Library Preparation Kit (for Illumina®), and captured by using HRR Panel v1.0. The variant analysis was performed by Vardict. Sequencing platform is NovaSeq 6000 with PE150.

Spike-in Capture Performance

Pic3. Spike-in capture performance of HRR Panel v1.0 DNA libraries were prepared by using the NadPrep DNA Library Preparation Kit (for Illumina®), and captured by using HRR Panel v1.0 and HiSNP Ultra Panel v1.0 with equimolar. The A. mapping rate, on-target rate, B. coverage uniformity and consistency were exhibited, respectively.Sample type: Human genomic DNA, male (Promega, G1471), Onco gDNA (Genewell, GW-OGTM800), and Onco SNV Wildtype gDNA (Genewell, GW-OGTM005). Sequencing platform is NovaSeq 6000 with PE150.

For research use only. Not for use in diagnostic procedures.